AM-2201 Powder
AM-2201 is a potent, non-selective synthetic cannabinoid of the aminoalkylindole type which acts as a full agonist at cannabinoid receptors CB1 and CB2 (EC50 = 38 nM and 58 nM, respectively)1. AM-2201 metabolites are also recognised to be full agonists1. Binding to the cannabinoid receptors triggers a reduction of intracellular cAMP levels by inhibiting adenylate cyclase2. In vitro studies have shown 41 and 18 times more affinity for CB1 and CB2 receptors, respectively, when compared to Δ9-THC and revealed dosage-dependent cytotoxicity and chromosomal aberrations in primary cell lines3. Studies on experimental mice models showed bradycardia, hypothermia, and catalepsy1.
